Causes Of Kawasaki Syndrome

Causes Of Kawasaki Syndrome

Kawasaki syndrome is a commonly known name for lymph node syndrome and mucocutaneous lymph node syndrome.

Infants are most prone to this disease where it affects their major body organs like skin, blood vessels, and lymph nodes.  Aneurysmal dilations caused due to the syndrome makes it all the more threatening.If not or partially cured, the mortality rate can reach up to 1 percent, while the mortality rate stays at 0.01 percent if proper treatment is provided.

Few symptoms and the effects like presence of edema in feet and hands, enlarged cervical lymph nodes, and fever are noticed in infants exposed to the disease. These identifications were made possible by the only initiative taken by Dr. Tomisaku Kawasaki of Japan. 

With a little controversy, the originating cause of this disease is said to be a result of interaction of environmental and genetic factors. Infection is also known as one of the major causes.

With the absence of any particular evidence, recently, studies and theories point towards immunological causes. The matter of conflict is that the cause is actually an antigenic or a superantigen.

An interesting study done by Children’s Hospital Boston shows the relation of Kawasaki syndrome with that of dusty and unhealthy environment created by cleaning carpet or dirty water or lavatories. 

Researchers have found a connection between a single nucleotide polymorphism in the ITPKC gene, which is responsible for coding the enzyme that negatively regulates the activation of T-cell activation.

Another study helps in establishing a fact that Japanese children, because of the genetic susceptibility, are more prone to the disease. Here the genetic factor is overcoming the environmental influence.

The HLA-B51 is serotype is now known to have a relation with the endemic instances of Kawasaki syndrome.

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Causes Of Kawasaki Syndrome