The Different Types Of Sickle Cell Anemia

The Different Types Of Sickle Cell Anemia

Sickle cell condition is inherited from parents the same way some of the traits are inherited. Sickle cell anemia is caused by a recessive allele. The type of hemoglobin a person makes in the red blood cells depends on what hemoglobin genes the person has inherited from the parents.

A person who receives defective gene from both the parents develops the sickle cell anemia.

A person who receives one defective and one healthy allele remains healthy but he has the sickle cell trait in him and he becomes a carrier to pass it on to the next generation. If both the parents are carriers of the disease, there is 25 percent chance that their child develops sickle cell anemia and 50 percent chance that the child becomes a carrier.

This disease mostly affects African Americans and its prevalence is approximately 1 in 5000.

Sickle cell gene is caused by a mutation of the hemoglobin gene. Hemoglobin is part of the red blood cell that carries oxygen. Hemoglobin A is the normal hemoglobin and hemoglobin S is sickle cell hemoglobin.

There are many different types of sickle cell diseases. The common ones are hemoglobin SS, hemoglobin SC, and Sickle Beta Thalassemia.

Hemoglobin SS -- The patient inherits hemoglobin S gene from both the parents. This is known as homozygous sickle cell disease.

Hemoglobin SC -- The patient inherits hemoglobin S gene from one parent and hemoglobin C from the other parent. This is known as heterozygous sickle cell disease.

Sickle Beta Thalassemia -- Hemoglobin S gene is inherited from one parent and beta thalassemia gene is inherited from the other parent. This is a heterozygous sickle cell disease.

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The Different Types Of Sickle Cell Anemia