Do Lipids Cause Bacterial Growth In Central Venous Catheters

Do Lipids Cause Bacterial Growth In Central Venous Catheters ?

An essential part of modern medicine is the use of intravenous catheters. However, at times this leads to infection which gives rise to other complications and can even result in death. 90 percent of hospital related bloodstream infections result from central venous catheters.

There are four potential sites for catheter related infections. These are at the point of insertion in the skin, at the hub of the catheter, haematogeneous seeding from a distant infection and from an infected infusate. For a positive diagnosis of catheter related infection the catheter normally requires to be removed. Of late, however, techniques have evolved which permit the diagnosis of CRI with the catheter in situ.

Administered peripherally, lipid emulsion has been assessed for its capability in encouraging microbial growth. The tests were carried out at room temperature. It was found that cultures of Candida albicans and Staphylococcus aureus were able to multiply in the emulsion. So too did three species of gram negative rods. However, an alteration in inoculum size made no difference to the growth rate. A comparison of lipid emulsion with amino acid-glucose solution confirmed other reports that total parenteral nutrition (lipid emulsion) only retarded fungal multiplication but completely repressed the growth of certain bacteria. In an attempt to simulate actual conditions, to the lipid emulsion was added human serum at the catheter tip. The outcome of the study was that the proliferation of Candida albicians and Staphylococcus aureus continued as before whereas the growth of Escherichia coli was totally stemmed.

It cannot, hence, be stated definitively that lipids cause bacterial growth in central venous catheters.

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Do Lipids Cause Bacterial Growth In Central Venous Catheters