A series of genetic studies have identified that D-amino acid oxidase activator (DAOA also known as G-72) which is found in various parts of nervous system, spinal cord and testis is thought to interact with D- amino acid oxidase (DAAO also known as DAO OXDA and DAMOX), a peroxisomal enzyme, and its gene was associated with schizophrenia (A mental disorder characterized by abnormalities in the perception or expression of reality).
The main function of D-amino acid oxidase is to oxidize D-amino acids to corresponding amino acids, producing ammonia and hydrogen peroxide.
The study aims to further elucidate whether DAAO activity is altered in schizophrenia. The statistical data obtained from the study also suggests a potential role for DAAO in susceptibility to depressive symptoms in schizophrenia, but a more general role of DAO in effective disorders cannot be excluded.
Specific DAAO activity was measured in postmortem cortex samples of bipolar disorder, major depression and schizophrenia patients, and normal controls (n=15 per group). The mean DAAO activity was two-fold higher in schizophrenia patients group compared with control group. However, there was no co-relation between DAAO activity and age, duration of disease, PH of the tissue, gender of a patient and patients lifestyles (smoking and alcohol consumption).The medications like neoroleptics that block dopamine receptors or reduce excess quantities of dopamine in the brain unfortunately shows unpleasant side effects in the form significantly increase in D- amino acids oxidase activity that interfere with the recovery of patient suffering from schizophrenia. However, there was no co-relation between the cumulative life-time antipsychotic drug usage and D- amino acid oxidase levels. These findings reveals that D-serene availability in the nervous system may be altered is schizophrenia because of increased D-amino acid degradation by DAAO.
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