Parkinson’s disease is a degenerative progressive disease of the central nervous systems occurring mostly after the age of 50.It is characterized by muscular tremor, slowing of movement, partial facial paralysis, and posture instability. It occurs when cells in one of the movement-control centers of the brain begins to die for unknown reasons. Parkinson’s disease was first noted by British physician, James Parkinson, in the early 1800s.
Over the years there were various developments and advancement in the treatment and medication prescribed for the treatment of Parkinson’s disease. One such treatment adopted nowadays for the treatment for Parkinson’s disease is deep brain stimulation.Deep Brain Stimulation for Parkinson Disease:
Since conventional treatment may not work in all patients. Deep brain stimulation has proved to be effective in treating Parkinson’s disease and essential tremors. The procedure of deep brain stimulation for Parkinson’s disease involves the surgical implantation of a thin, insulated wire lead with four electrodes at the tip, into a specific area of the brain (globus pallidus). The wire run under the skin to a battery-operated pulse generator implanted near the clavicle (collarbone).
The generator sends continuous electrical impulses to the brain, which in turn block brain signals that cause the uncontrollable tremors in Parkinson’s disease. The patient can turn the generator on or off by swiping a special magnet over the generator. Deep brain stimulation improves the movement symptoms of Parkinson’s disease by 25-75 percent, depending on how carefully electrodes are placed in the optimal target area, and how effectively the settings can be adjusted.
Deep brain stimulation is mainly recommended to patients with severe symptoms not controlled by medication or other therapy, and helps to avoid destructive procedures like pallidotomy. It should not be considered as the primary mode of treatment for Parkinson’s disease, and may not be successful in all cases. Like any other surgical procedure, deep brain stimulation is not without any risks. It involves the risk of brain hemorrhage and infection as well as the risk of general anesthesia. The older the patient, the higher the risk of complications.New Advancement in Drug Therapy for Parkinson's Disease:
Levodopa-carbidopa brand name sinemet has long been the drug used to treat Parkinson’s disease. It is used to relieve tremors and weakness associated with it. Sinemet is actually two separate drugs, levedopa, which treats the symptoms and carbidopa, which keeps vitamin B-6 from destroying the levedopa. Being able to combine Sinemet and Azilect means greater improvements in the advanced stages of the disease. Sinemet need to be taken every four to eight hours to be completely effective against tremors. By adding azilect, it means less discomfort and more control of symptoms when the sinemet begins to wear off.
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