Parkinson’s disease is a common disorder that affects the brain's ability to control movements. It is occurs mostly after the age of 50. In Parkinson's, the brain cells deteriorate in an area of the brain called the substantia nigra. The loss of these specific brain cells are the cornerstone of signs and symptoms of Parkinson's as well as the target of treatment.
Parkinson’s disease gradually worsens with passage of time, although the rate of worsening may vary from person to person, and the progression is also very slow. Majority of people who are treated with Parkinson's are able to live many years without serious disability. Nowadays a number of treatment options are available that can help to manage symptoms and improves a person’s quality of life.
Although Parkinson’s disease itself is not fatal, and its progression is also very slow, but it increases the risk of dying from Parkinson’s related complications such as falls, choking or pneumonia. Sometimes due to complications sudden worsening of Parkinson’s disease occurred and it is termed as acute akinesia.
Acute Akinesia is defined as sudden deterioration in motor performance that persists for more than 48 hours. Acute akinesia, sometimes referred to as Parkinson's crisis, is rare, but a life threatening complication of Parkinson disease. Acute akinesia is not a properly defined complication occurring during the course of Parkinson's disease with infectious disease, bone fractures, and gastrointestinal tract diseases and due to sudden discontinuation of Levodapa (a drug used in treatment of Parkinson’s disease).
There is acute worsening of Parkinson's symptoms and the patient becomes unresponsiveness to current treatment. The major clinical symptoms are represented by a severe akinetic state with frequent cognitive and psychotic disturbances and dysphasia and aphonia, with opportunistic infections in most severe form.
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